YSOPIA Bioscience’s game-changing strategy is built around developing living single-strain biotherapies based on carefully selected keystone bacteria.
> Discover our approach
Obesity & associated metabolic disorders
After demonstrating strong efficacy results in preclinical animal models, YSOPIA successfully completed the Phase 1 clinical study for its Xla1 biotherapy in July 2021 and demonstrated its excellent safety and tolerability profile, as well as first efficacy results.
> Discover safety and first efficacy results of Xla1 biotherapy
Following this success, YSOPIA is preparing to launch a Phase 2 clinical trial to establish the first proof of concept for Christensenella’s efficacy in humans in treating obesity and its associated metabolic abnormalities.
This is built on our seminal work published in Cells (Mazier et al. 2021) demonstrating in vivo that our clinical candidate Xla1 limits body weight gain and normalizes several metabolic markers.
YSOPIA has identified a lead candidate to relieve Crohn’s disease associated symptoms and slow down disease progression.
Discover the articles we published in Scientific Reports: Relizani et al. 2022 and Kropp et al. 2021. Our team has selected from our proprietary strain library a lead candidate with high anti-inflammatory potential and protective action on gut epithelium.
As part of this program, YSOPIA has selected a clinical candidate having demonstrated strong in vivo efficacy on inflammation and lung functions.
We have achieved the formulation feasibility and cleared the regulatory hurdles associated with developing this new biotherapy. Continue our development plan to the clinical phase is the further step for this program.
Over the last 5 years, there has been increasing evidence that the gut microbiome is associated with neurological and behavioral disorders, in what is known as the “gut-brain axis”.
Multiple complex mechanisms of action are at play in this relationship, and although there is still much to discover, there is strong evidence that the gut microbiome affects neurotransmitter metabolism and neuroinflammation.
YSOPIA Bioscience has therefore launched research in this exciting area to harness the potential of carefully selected bacteria strains of Christensenellaceae to treat mood disorders such as depression and anxiety.
The field of cancer therapy has been revolutionized by the use of immunotherapy. The microbiome breakthrough science today paves the way for innovative biotherapies to potentiate the effectiveness of these cancer immunotherapies.
YSOPIA is exploring the role of specific keystone bacteria with high therapeutic potential in the oncology field based on a strong understanding of their mechanisms of action.